Novel Drug Delivery Systems-II - M.Pharm Previous Question Paper- Nov 2012

M. Pharm ll semester Regular & Supplementary Examinations, November 2012

NOVEL DRUG DELIVERY SYSTEMS II

(Pharmaceutics)

Time: 3 hours                                                                                                    Max Marks: 60

Answer any FIVE questions
All questions carry equal marks

1 (a) what are various physiological factors affecting oral bioavailability ofdrugs? Explain any two in detail.

(b) what are efflux transport systems? write its significance.

2 (a Explain the structure and composition of M-Cells and Payer's patchesin Gm.

(b) Discuss in brief about lymphatic transport of drugs.

3.(a)  What is gene therapy ? Write in brief about exvivo and invivo gene therapy.

(b) write in brief about liposomal gene delivery systems.

4 (a) What is genetic polymorphism? How will it affect drug disposition?

(b) Outline the gene therapy for diabetes and cystic fibrosis.

5 (a) Discuss the challenges in the delivery of protein and peptide based drugs.

(b) What are engineered proteins? Explain about DNA technology for engineered proteins

6 (a) Explain various types of immunization.

(b) Discuss in brief about the development of micro particles for vaccine delivery.

7 (a) What is active and passives drug targeting? Give examples.

(b) Explain various approaches for tumor targeting.

8 Write a note on:
(a) Permeation enhancers.
(b) Gene expression.
(c) Single dose vaccine delivery