M Pharm II nd Semester Supplementary Examinations, April 2013
NOVEL DRUG DELIVERY SYSTEMS Il
(Pharmaceutics)
Time: 3 hours Max Marks: 60
Answer any FIVE questions
All questions carry equal marks
All questions carry equal marks
1 (a) Explain the role of any two physiological factors affecting oral bioavailability of drugs with examples.
(b) Enumerate various transport mechanisms across the cell membrane. Add a note on efflux transporter systems.
2 (a) What are "m cells and peyer's patehes in GIT? Explain their significance.
(b) Explain in brief about the lymphatic transport of drugs.
3 (a) what is gene therapy? What are potential target diseases for gene therapy? Add a note on gene expression system.
(b) Explain the bio-distribution and pharmacokinetics of liposomal gene delivery systems.
4 (a) Define genomics, proteomics and bio-informatics. Write in brief about human genome project.
(b) Outline the gene therapy for hepatitis and AIDs.
5 (a) What are the difficulties and challenges in the delivery of biotechnology based drugs?
(b) Explain about DNA technology for engineered proteins with an example.
6 (a) What is immunization? Explain various types of it.
(b) Explain the development of single dose vaccine delivery systems using biodegradable polymers.
7 (a) Explain various types of drug targeting with examples.
(b) Discuss in brief about molecular basis of drug targeting.
8 Write note on:
(a) Exvivo and Invivo gene therapy
(b) Micro particles for vaccine delivery
(c) Recombinant proteins
(a) Exvivo and Invivo gene therapy
(b) Micro particles for vaccine delivery
(c) Recombinant proteins
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