M.Pharm 2nd Semester Previous Question Paper Nov 2012 - BIOPHARMACEUTICS AND PHARMACOKINETICS

M.Pharm 2nd Semester Regular & Supplementary Examinations, November 2012

BIOPHARMACEUTICS AND PHARMACOKINETICS

(For students admitted in 2009, 2010 & 2011 only)

(Common Paper)

Time: 3 hours                                                                                               Max Marks: 60

Answer any FIVE questions
All questions carry equal marks

1. Elaborate in detail the bioavailability study protocol and result interpretation.

2. Explain in detail the physico- chemical properties affecting drug bioavailability.

3. Discuss the pharmacokinetic parameters with respect to non compartmental model after single oral administration.

4. Write a note on:
(a) Total clearance.
(b) Determination of loading and maintenance dose.

5. Discuss the concept behind non invasive methods in the determination of pharmacokinetic parameters.

6. Enumerate the significance of Michalis Menten kinetics.

7. Write the importance of dosing with respect to:
(a) Chronopharma cokinetics.
(b) Liver and renal disease states.

8. Outline the study design, regulations and criteria for bioequivalent studies.