BIOPHARMACEUTICS AND PHARMACOKINETICS - M.Pharm 2nd semester supplementary Examinations, April 2015

M.Pharm 2nd semester supplementary Examinations, April 2015

BIOPHARMACEUTICS AND PHARMACOKINETICS

(Common to Pharmaceutics, Pharmacology, Pharmacy Practice Industrial Pharmacy and Pharmaceutical Technology)

Max Marks: 60                                                                                          Time: 3 hours

Answer any FIVE questions
All questions carry equal marks

1. Describe about design of ailability and bioequivalence studies protocols with examples,

2. (a) Write about techniques for enhancing dissolution rate.

(b) Discuss about methods for assessing bioavailability

3. Explain about physiochemical properties influencing bioavailability with examples and add note on polymorphism and complexation.

4. (a) Define and determination of apparent volume of distribution and its importance.

(b) Add a note on recent trends merits and limitations and approaches of pharmacokinetic studies,

5. Discuss about estimation of pharmacokinetic parameters with emphasis on salivary and urinary compartments through non invasive methods.

6. Estimate and determine the following
(a) Elimination rate constant non-linearity,
(b) Biological half-life.
(c) Renal clearance and non-linear binding
(d) Hepatic clearance and dissolution limits.

7. Explain about one-two compartment models. And add on non compartmental model approaches to pharmacokinetics

8. Write short note on followings,
(a) Log time and extent of absorption.
(b) single dose oral administration.
(c) Bioequivalence study design.
(d) Chromopharmacokinetics.